Skip to content

Prenatal alcohol exposure (PAE) results in well‐characterised neurological, behavioural, and cognitive deficits in offspring. However, the effects on other health outcomes have not been comprehensively described. We used a systematic review methodology to survey published clinical and preclinical studies investigating a broad range of health outcomes in offspring with PAE. This study specifically reports on outcomes related to metabolism and body composition.  The preclinical studies provided evidence of glucose intolerance and/or insulin resistance; dyslipidemia and/or hypercholesterolemia; and increased adiposity in offspring with PAE. Due to the paucity of clinical studies, we recommend further studies be conducted to obtain a complete assessment of long‐term metabolic health outcomes in children and adults with PAE, particularly in those diagnosed with FASD.

Publication: Alcoholism: Clinical & Experimental Research

Date: May 2019

Authors: Akison, LK, Reid, N, Wyllie, M, Moritz KM

View Article

Page last updated 7 April 2020